abstract：:Establishment of a detection platform for glioblastoma-dendritic cell (DC) vaccine preparation and to determine the efficacy of the vaccine in a clinical trial. Autologous glioblastoma-DC vaccine was prepared from a glioblast specimen procured from surgical resection. The specimen was used to enrich the vaccine with p...

journal_title：Cell biochemistry and biophysics

authors： Jie X,Hua L,Jiang W,Feng F,Feng G,Hua Z

更新日期：2012-01-01 00:00:00

abstract：:The phosphatidylinositol 3-kinase/AKT (PI3K/AKT) pathway plays a critical role in human cancer. We determined the expression patterns of class I PI3K catalytic subunits and evaluated their importance in the development or progression of colorectal cancer (CRC). For this purpose, expression of class I PI3K isoforms was...

journal_title：Cell biochemistry and biophysics

authors： Cui B,Tao J,Yang Y

更新日期：2012-01-01 00:00:00

abstract：:We wished to study the efficacy and safety of the retrograde ligation of short hepatic veins (SHVs) and the right hepatic vein (HV) through the retrohepatic tunnel in patients who underwent hemihepatectomy due to large hepatic carcinoma in the right lobe of the liver. Right hemihepatectomy was performed in 23 patients...

journal_title：Cell biochemistry and biophysics

authors： Qin Q,Wang L,Li H,Li A,Ouyang J,Xie S,Liang Z

更新日期：2012-01-01 00:00:00

abstract：:Herpes simplex virus (HSV) is one of the most common viruses infecting humans and animals. Cellular adhesion is increased in HSV and plays a role in pathogenesis of inflammatory response during this viral infection. In our study, we studied a potential role of glycyrrhizin in disrupting cellular adhesion in HSV. We is...

journal_title：Cell biochemistry and biophysics

authors： Huang W,Chen X,Li Q,Li P,Zhao G,Xu M,Xie P

更新日期：2012-01-01 00:00:00

abstract：:In this study, we analyzed causes of abdominal hemorrhage after reduced-size liver transplantation in rat. Healthy SD rats (weight range of 260-280 g) underwent liver transplantation, the donors were female and the recipients were male rats. The recipients were, on average, by <10 g heavier than the donors. All operat...

journal_title：Cell biochemistry and biophysics

authors： Jing L,Li L,Jiang-Hua R,Sheng-Ning Z,Zhu L,Lai-Bang L,Jiang L

更新日期：2011-12-01 00:00:00

abstract：:We identified significantly higher expression of the genes glycogen debranching enzyme 6 (AGL), enolase 1 (ENOSF1), ectonucleotide pyrophosphatase 2 (ENPP2_1), glutathione S-transferase 3 (GSTM3_3) and mannosidase (MAN2B2) from human left cerebrums versus chimpanzees. Yet the distinct low- and high-expression AGL, ENO...

journal_title：Cell biochemistry and biophysics

authors： Sun L,Wang L,Jiang M,Huang J,Lin H

更新日期：2011-12-01 00:00:00

abstract：:The study's objective was to evaluate the applicability of different endovascular methods for treatment of refractory type of Budd-Chiari syndrome (BCS) under specific scenarios frequently encountered in patients. The treatment methods were evaluated in 197 patients with the following four types of refractory BCS: les...

journal_title：Cell biochemistry and biophysics

authors： Gao Y,Chen S,Yu C

更新日期：2011-11-01 00:00:00

abstract：:A fast-track clinical pathway is designed to streamline patient care delivery and maximize cost effectiveness. It has decreased postoperative length of stay (LOS) and hospital charges for many surgical procedures. However, data on clinical pathways after liver surgery are sparse. This study examined whether use of a f...

journal_title：Cell biochemistry and biophysics

authors： Lin DX,Li X,Ye QW,Lin F,Li LL,Zhang QY

更新日期：2011-11-01 00:00:00

abstract：:Filamin (FLN) plays an important role in differentiation, migration, and signal transduction in vascular smooth muscle cells (VSMCs). We hypothesized that suppression of FLN expression would inhibit differentiation and migration of VSMCs, and interrupt the phenotype switch of these cells. We designed and tested differ...

journal_title：Cell biochemistry and biophysics

authors： Zhu G,Chen H,Zhang W

更新日期：2011-09-01 00:00:00

abstract：:To study the protective effect of mitochondrial ATP-sensitive K(+) channel (mitoK(ATP) channel) opener, nicorandil, combined with Na(+)/Ca(2+) exchange blocker KB-R7943 on myocardial ischemia-reperfusion injury in isolated rat hearts; the isolated rat heart was perfused by modified Langendorff device, after 15-min bal...

journal_title：Cell biochemistry and biophysics

authors： Jia D

更新日期：2011-07-01 00:00:00

abstract：:Cholesystolithiasis is often associated with common bile duct stones (CBDS). In order to assess the choice of surgery in terms of effectiveness and complications in the treatment of CBDS, we have compared three surgical procedures, viz., laparoscopic choledocholithotomy T-tube drainage (LCH-TD), laparoscopic cholecyst...

journal_title：Cell biochemistry and biophysics

authors： Gu AD,Li XN,Guo KX,Ma ZT

更新日期：2011-04-01 00:00:00

abstract：:Many macrophage functions are modulated by fatty acids (FAs), including cytokine release, such as tumor necrosis factor-α (TNF-α). TNF-α is of great interest due to its role in the inflammation process observed in several diseases such as rheumatoid arthritis, atherosclerosis, and obesity. However, the mechanisms by w...

journal_title：Cell biochemistry and biophysics

authors： de Lima-Salgado TM,Alba-Loureiro TC,do Nascimento CS,Nunes MT,Curi R

更新日期：2011-03-01 00:00:00

abstract：:Reactive oxygen species (ROS) are involved in a variety of biological phenomena, such as mutation, carcinogenesis, inflammation, aging, development, and signal transduction. Intracellular generation of ROS might lead to the activation of redox signaling or oxidative stress. Nonetheless, it is difficult to estimate whe...

journal_title：Cell biochemistry and biophysics

authors： Martinovich GG,Martinovich IV,Cherenkevich SN,Sauer H

更新日期：2010-11-01 00:00:00

abstract：:The role of bone morphogenetic protein 4 (BMP4) in gliomas is not clear. We hypothesized that BMP4 inhibits proliferation in the brain glioma cell line U251 through a signaling pathway involving BMP4 and the mothers against decapentaplegic homolog 4 (SMAD4) protein. We exposed U251 cells to Adriamycin (1 g) for 48 h; ...

journal_title：Cell biochemistry and biophysics

authors： Liu B,Tian D,Yi W,Wu L,Cai Q,Dong H,Shen H,Ji B,Wang L,Zhang S,Ruan D,Chen Q

更新日期：2010-11-01 00:00:00

abstract：:Objective of this article is to construct and characterize a three-layered small-caliber, artificial vascular stent. The outer layer of the stent consisted of small intestine submucosa (SIS), the middle layer was the polydioxanone (PDS) vascular stents, and the inner layer. The SIS and PDS were attached with 8-0 PDS t...

journal_title：Cell biochemistry and biophysics

authors： You Q,Wang F,Duan L,Du X,Xiao M,Shen Z

更新日期：2010-05-01 00:00:00

abstract：:The aim of this study is to set up single molecular secreted phosphoprotein 1 (SPP1) upstream invasive network of lung adenocarcinoma. This paper proposed an integrated method based on linear programming and a decomposition procedure with integrated analysis of the significant function cluster using Kappa statistics a...

journal_title：Cell biochemistry and biophysics

authors： Sun Y,Wang L,Jiang M,Huang J,Liu Z,Wolfl S

更新日期：2010-04-01 00:00:00

abstract：:Red blood cell (RBC) adhesion to vessel wall endothelium is a potent catalyst of vascular occlusion and occurs in oxidative stress states such as hemoglobinopathies and cardiovascular conditions. These are often treated with vitamin E (VitE), a "classic" antioxidant. In this study, we examined the effects of VitE on R...

journal_title：Cell biochemistry and biophysics

authors： Koshkaryev A,Barshtein G,Yedgar S

更新日期：2010-04-01 00:00:00

abstract：:Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) is a cellular receptor for hepatitis C virus for the binding of viral envelope glycoprotein E2. Interaction of DC-SIGN with the E2 may evoke cellular signal transduction implicated in viral pathogenesis. We developed a cell model ...

journal_title：Cell biochemistry and biophysics

authors： Chen QL,Zhu SY,Bian ZQ,Zhao LJ,Cao J,Pan W,Qi ZT

更新日期：2010-01-01 00:00:00

abstract：:Bioactive materials present important micro-environmental cues that induce specific intracellular signaling responses which ultimately determine cell behavior. For example, vascular endothelial cells on a normal vessel wall resist inflammation and thrombosis, but the same cells seeded on an artificial vascular graft o...

journal_title：Cell biochemistry and biophysics

authors： Caplan MR,Shah MM

更新日期：2009-01-01 00:00:00

abstract：:Surfactin, purified from Bacillus subtilis natto TK-1, inhibited proliferation of human breast cancer MCF-7 cells in a dose- and time-dependent manner, with IC(50) at 24, 48, and 72 h of 82.6, 27.3, and 14.8 microM, respectively. Surfactin-induced cell death was considered to be apoptotic by observing the typical apop...

journal_title：Cell biochemistry and biophysics

authors： Cao X,Wang AH,Jiao RZ,Wang CL,Mao DZ,Yan L,Zeng B

更新日期：2009-01-01 00:00:00

abstract：:Active transport is essential for cellular function, while impaired transport has been linked to diseases such as neuronal degeneration. Much long distance transport in cells uses opposite polarity molecular motors of the kinesin and dynein families to move cargos along microtubules. It is clear that many types of car...

journal_title：Cell biochemistry and biophysics

authors： Sataric MV,Budinski-Petkovic L,Loncarevic I,Tuszynski JA

更新日期：2008-01-01 00:00:00

abstract：:The coherent electromagnetic radiation (EMR) of the frequency of 51.8 and 53 GHz with low intensity (the power flux density of 0.06 mW/cm(2)) affected the growth of Escherichia coli K12(lambda) under fermentation conditions: the lowering of the growth specific rate was considerably (approximately 2-fold) increased wit...

journal_title：Cell biochemistry and biophysics

authors： Tadevosyan H,Kalantaryan V,Trchounian A

更新日期：2008-01-01 00:00:00

abstract：:There are over 10,000 C2H2-type zinc finger (ZF) domains distributed among more than 1,000 ZF proteins in the human genome. These domains are frequently observed to be involved in sequence-specific DNA binding, and uncharacterized domains are typically assumed to facilitate DNA interactions. However, some ZFs also fac...

journal_title：Cell biochemistry and biophysics

authors： Brayer KJ,Kulshreshtha S,Segal DJ

更新日期：2008-01-01 00:00:00

abstract：:Given that vascular endothelial cells play an important role in the modulation of vascular structure and function, we hypothesized that endocardial endothelial cells (EECs) may have a modulator role in regulating the cardiac interstitial cells. Endocardial endothelial cells were isolated from freshly collected pig hea...

journal_title：Cell biochemistry and biophysics

authors： Kuruvilla L,Nair RR,Umashankar PR,Lal AV,Kartha CC

更新日期：2007-01-01 00:00:00

abstract：:The calcium channel gamma subunits comprise an eight-member protein family that share a common topology consisting of four transmembrane domains and intracellular N- and C-termini. Although the first gamma subunit was identified as an auxiliary subunit of a voltage-dependent calcium channel, a review of phylogenetic, ...

journal_title：Cell biochemistry and biophysics

authors： Chen RS,Deng TC,Garcia T,Sellers ZM,Best PM

更新日期：2007-01-01 00:00:00

abstract：:The remarkable ability of living cells to sense, process, and respond to mechanical stimuli in their environment depends on the rapid and efficient interconversion of mechanical and chemical energy at specific times and places within the cell. For example, application of force to cells leads to conformational changes ...

journal_title：Cell biochemistry and biophysics

authors： Lele TP,Kumar S

更新日期：2007-01-01 00:00:00

abstract：:Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This...

journal_title：Cell biochemistry and biophysics

authors： Karlsson HK,Zierath JR

更新日期：2007-01-01 00:00:00

abstract：:Previous work from this laboratory has demonstrated that transplantation of allogeneic thymic tissue as part of a composite vascularized graft is far more successful in terms of both engraftment and long-term survival than transplantation of thymic tissue or cells alone. We have subsequently extended this concept to t...

journal_title：Cell biochemistry and biophysics

authors： Vallabhajosyula P,Griesemer A,Yamada K,Sachs DH

更新日期：2007-01-01 00:00:00

abstract：:The PCI domain comprises approx 200 amino acids and is found in subunits of the eukaryotic translation initiation factor 3 (eIF3), the 26S proteasome and the COP9/signalosome complexes. The PCI domain is involved in protein-protein interaction, and mouse INT6 truncated proteins lacking the PCI domain show cell maligna...

journal_title：Cell biochemistry and biophysics

authors： Murai MJ,Carneiro FR,Gozzo FC,Ierardi DF,Pertinhez TA,Zanchin NI

更新日期：2006-01-01 00:00:00

abstract：:The ubiquitous Na+/H+ exchanger NHE1 is regulated by protein phosphorylation events, but the mechanisms involved are incompletely understood. We recently cloned NHE1 from the red blood cells of the winter flounder, Pleuronectes americanus (paNHE1), and demonstrated its activation by osmotic cell shrinkage, beta-adrene...

journal_title：Cell biochemistry and biophysics

authors： Holt ME,King SA,Cala PM,Pedersen SF

更新日期：2006-01-01 00:00:00

abstract：:The peritoneal mesothelium acts as a regulator of serosal responses to injury, infection, and neoplastic diseases. After inflammation of the serosal surfaces, proinflammatory cytokines induce an "activated" mesothelial cell phenotype, the mitochondrial aspect of which has not previously been studied. After incubation ...

journal_title：Cell biochemistry and biophysics

authors： Stadlmann S,Renner K,Pollheimer J,Moser PL,Zeimet AG,Offner FA,Gnaiger E

更新日期：2006-01-01 00:00:00

abstract：:Right ventricular hypertrophy and failure are prominent features in cyanotic congenital heart disease, tetralogy of Fallot (TF). Patients with TF require primary cardiac surgery at a very young age. To gain insight into the underlying molecular mechanisms of right ventricular hypertrophy and to identify gene(s) involv...

journal_title：Cell biochemistry and biophysics

authors： Sharma HS,Peters TH,Moorhouse MJ,van der Spek PJ,Bogers AJ

更新日期：2006-01-01 00:00:00

abstract：:The mechanism of induction of cardiomyocyte (CM) dedifferentiation, as seen in chronic hibernating myocardium, is largely unknown. Recently, a cellular model was proposed consisting of long-term cocultures of adult rabbit CMs and cardiac fibroblasts in which typical structural characteristics of hibernation-like dedif...

journal_title：Cell biochemistry and biophysics

authors： Driesen RB,Verheyen FK,Dispersyn GD,Thoné F,Lenders MH,Ramaekers FC,Borgers M

更新日期：2006-01-01 00:00:00

abstract：:Many of the structural domains involved in Ca2+ channel (CACN) inactivation are also involved in determining their sensitivity to antagonist inhibition. We hypothesize that differences in inactivation properties and their structural determinants may suggest candidate domains as targets for the development of novel, se...

journal_title：Cell biochemistry and biophysics

authors： Cox RH,Kathrins M

更新日期：2006-01-01 00:00:00

abstract：:The three-dimensional structure of the saccharopine reductase enzyme from the budding yeast Saccharomyces cerevisiae was determined to 1.7-A resolution in the apo form by using molecular replacement. The enzyme monomer consists of three domains: domain I is a variant of the Rossmann fold, domain II folds into a alpha/...

journal_title：Cell biochemistry and biophysics

authors： Andi B,Cook PF,West AH

更新日期：2006-01-01 00:00:00

abstract：:We investigated theoretically and experimentally the Ca2+-contraction coupling in rat tracheal smooth muscle. [Ca2+]i, isometric contraction and myosin light chain (MLC) phosphorylation were measured in response to 1 mM carbachol. Theoretical modeling consisted in coupling a model of Ca2+-dependent MLC kinase (MLCK) a...

journal_title：Cell biochemistry and biophysics

authors： Mbikou P,Fajmut A,Brumen M,Roux E

更新日期：2006-01-01 00:00:00

abstract：:Biomolecular behavior commonly involves complex sets of interacting components that are challenging to understand through solution-based chemical theories. Molecular assembly is especially intriguing in the cellular environment because of its links to cell structure in processes such as chemotaxis. We use a coarse-gra...

journal_title：Cell biochemistry and biophysics

authors： Puskar K,Ta 'asan S,Schwartz R,LeDuc PR

更新日期：2006-01-01 00:00:00

abstract：:Rotaviruses are one of the worldwide leading causes of gastroenteritis in children under 5 yr old. The rotavirus nonstructural NSP5 is a phosphoprotein implicated in viroplasms formation, whereas NSP6 could have a possible regulatory role of NSP5. It has been reported that N- and C-termini of NSP5 are important for th...

journal_title：Cell biochemistry and biophysics

authors： Samaniego-Hernández M,De León-Rodriguez A,Aparicio-Fabre R,Arias-Ortiz C,Barba de la Rosa AP

更新日期：2006-01-01 00:00:00

abstract：:The functions of membrane proteins are highly dependent on their phospholipid environment. In this article, we have used a hydrophobic photolabeling method to study the noncovalent interactions between plasma membrane calcium pump (PMCA) and surrounding phospholipids. With this approach, we determined (1) the number o...

journal_title：Cell biochemistry and biophysics

authors： Villamil Giraldo AM,Castello PR,González Flecha FL,Delfino JM,Rossi JP

更新日期：2006-01-01 00:00:00

abstract：:Synaptic glutamate receptors play a prominent role in the excitatory neurotransmission in the vertebrate central nervous system. Although elucidation of the functional properties of glutamate receptors using electrophysiologic analyses has yielded important information, methodological and technological limitations hav...

journal_title：Cell biochemistry and biophysics

authors： Vaithianathan T,Manivannan K,Kleene R,Bahr BA,Dey MP,Dityatev A,Suppiramaniam V

更新日期：2005-01-01 00:00:00